Two simultaneous mycetomas caused by Fusarium verticillioides and Madurella mycetomatis

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Two simultaneous mycetomas caused by Fusarium verticillioides and Madurella mycetomatis

Mycetoma is a chronic granulomatous disease, classified into eumycetoma caused by fungi and actinomycetoma due to aerobic filamentous actinomycetes. Mycetoma can be found in geographic areas near the Tropic of Cancer. Mexico is one of the countries in which actinomycetoma is endemic. We report an extraordinary case of an adult male with double eumycetoma caused by Madurella mycetomatis and Fusa...

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Eumycetoma on the foot caused by Madurella mycetomatis: amputation after significant worsening during pregnancy.

Mycetoma is a chronic, subcutaneous infection caused by traumatic inoculation through the skin of some types of filamentous aerobic bacteria (actinomycetoma) and true fungi (eumycetoma) (1, 2). It is considered a neglected disease with high morbidity and major effects on the patient’s quality of life (1–3). Few published cases have examined mycetoma during pregnancy (4–7). We report here a case...

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Madurella mycetomatis Is Highly Susceptible to Ravuconazole

The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads to complications and unnecessary amputations, and its comparatively high cost in endemic areas. Hence, an effective and affordable drug is required to improve therapeutic outcome. E1224 is a potent orally available, broad-spectrum triazole currently being developed fo...

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In vitro antifungal activity of isavuconazole against Madurella mycetomatis.

Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, wit...

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In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine.

Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains were determined. It appeared that posaconazole was highly active against M. my...

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ژورنال

عنوان ژورنال: Revista do Instituto de Medicina Tropical de São Paulo

سال: 2017

ISSN: 0036-4665

DOI: 10.1590/s1678-9946201759055